1-(3-Bromo-5-chloro-pyridin-4-yl)-ethanol → 1-[3-Chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol

Participants

Reaction Steps

1-[3-Chloro-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol is synthesized according to the procedure of Suzuki Coupling Method VI using 1-(3-bromo-5-chloro-pyridin-4-yl)-ethanol (which is prepared according to Step 1 of Example 78) and crude 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (that is prepared according to Step 4 of Example 105).

Provenance & Evidence