反应详情

Phosphorous tribromide (30 μL, 323 μmol) was added to a stirred solution of crude (4-(5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazol-3-yl)phenyl)methanol (83 mg, 215 μmol) at 0° C. The ice bath was removed and stirring was continued for 16 h. The reaction mixture was diluted with dichloromethane and water. The dichloromethane extract was washed with satd. Aqueous NaHCO3 solution, brine, dried (Na2SO4), filtered, and evaporated under reduced pressure to obtain crude 3-(4-(bromomethyl)phenyl)-5-(((1-(4-chlorophenyl)cyclobutyl)methoxy)methyl)-1,2,4-oxadiazole (91 mg, 95% crude yield). LC/MS: m/e 448.92 (M+H)+.

1. customThe ice bath was removed
2. additionThe reaction mixture was diluted with dichloromethane and water
3. extractionThe dichloromethane extract
4. washwas washed with satd
5. dry with materialAqueous NaHCO3 solution, brine, dried (Na2SO4)
6. filtrationfiltered
7. customevaporated under reduced pressure