1-(3-Bromopyridin-4-yl)ethanol → 1-[3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol

Participants

Role	Name	HCID	Charge
Reactant	1-(3-Bromopyridin-4-yl)ethanol	HCID 66797853	—
Reactant	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydro-1,8-naphthyridine	HCID 118989928	—
Product	1-[3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol	HCID 117667083	—

Reaction Steps

1-[3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-4-yl]-ethanol is synthesized according to the procedure of Suzuki Coupling Method VI using 1-(3-bromo-pyridin-4-yl)-ethanol and crude 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (which is prepared according to Step 4 of Example 105).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09181272B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-99878417b3c94a48aac2edf7c222325d
Source note	uspto-grants-2015_11