HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Benzyloxy-ethyl)-5-bromo-nicotinonitrile → 4-(1-Benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Benzyloxy-ethyl)-5-bromo-nicotinonitrile | HCID 117667424 | — |
| Reactant | 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydro-1,8-naphthyridine | HCID 118989928 | — |
| Product | 4-(1-Benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile | HCID 117667455 | — |
Reaction Steps
4-(1-Benzyloxy-ethyl)-5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-nicotinonitrile is synthesized according to the procedure of Suzuki Coupling Method VI using 4-(1-benzyloxy-ethyl)-5-bromo-nicotinonitrile and crude 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydro-[1,8]naphthyridine (which is prepared according to Step 4 of Example 105).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7be99ff27704400d9829bbc42b27c5e6 |
| Source note | uspto-grants-2015_11 |