1,1'-Carbonyldiimidazole → HCID 86305424, compound

Participants

Reaction Steps

To a suspension of [5-(8-carbamoyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-acetic acid (25 mg, 0.080 mmol) in DMF (1.5 mL) is added 1,1′-carbonyldiimidazole (14 mg, 0.088 mmol) and the mixture is stirred at room temperature for 16 h. 4,4-Difluoro-piperidine hydrochloride salt (15 mg, 0.096 mmol) and N,N-diisopropylethylamine (0.042 mL, 0.24 mmol) are added and stifling continues for an additional 16 h. H2O is added and the resulting precipitate is collected by filtration to afford 21 mg of the titled product.

Provenance & Evidence