HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-(5-bromo-pyridin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester → 3-bromo-5-((R)-piperidin-3-yloxy)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-(5-bromo-pyridin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 117667237 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-bromo-5-((R)-piperidin-3-yloxy)-pyridine | HCID 117667565 | 120.1% |
Reaction Steps
A solution of (R)-3-(5-bromo-pyridin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (596 mg, 1.7 mmol) in MeOH (5 mL) and HCl solution in 1,4-dioxane (4N; 1.5 mL) is stirred at room temperature for 16 h. The mixture is concentrated to provide 525 mg 3-bromo-5-((R)-piperidin-3-yloxy)-pyridine as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-8237b17ba3c44a49b679c8846484354f |
| Source note | uspto-grants-2015_11 |