Ethanesulfonyl chloride → HCID 118500702, compound

Participants

Reaction Steps

To a vial is added (1R)-1-(5-bromo(3-pyridyl)ethylamine (300 mg, 1.26 mmol) in 3 ml of CH2Cl2, followed by the addition of N,N-diisopropylethylamine (490 mg, 3.79 mmol). Then ethanesulfonyl chloride (195 mg, 1.52 mmol) is added. The reaction mixture is stirred at room temperature for 2 hours. The reaction mixture is diluted with DCM, washed with water, brine, dried over anhydrous Na2SO4, filtered and concentrated to give the crude product. Purification by the flash column chromatography affords 278 mg of ethanesulfonic acid [(R)-1-(5-bromo-pyridin-3-yl)-ethyl]-amide.

Provenance & Evidence