Ammonium formate → HCID 117667610, compound

Participants

Reaction Conditions

Reaction Steps

5-(8-carbamoyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-4-cyano-3′,6′-dihydro-2′H-[3,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (100 mg, 0.22 mmol), 10% Pd on carbon (88 mg, 0.083 mmol) and ammonium formate (210 mg, 3.3 mmol) are mixed in MeOH (2.0 mL). The reaction mixture is heated at 60° C. for 24 hrs. Then the solid is filtered and the filtrate is concentrated to give the crude 5-(8-carbamoyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-4-cyano-3′,4′,5′,6′-tetrahydro-2′H-[3,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester which is used in the next step without purification.

Provenance & Evidence