Acetic Acid → HCID 117667718, compound

Participants

Reaction Steps

The crude 6-(4-cyano-1′,2′,3′,4′,5′,6′-hexahydro-[3,4]bipyridinyl-5-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (0.22 mmol), acetic acid (0.025 mL, 0.43 mmol) and triethyl amine (0.091 mL, 0.65 mmol) are mixed in acetonitrile (2.5 mL). Then TBTU (104 mg, 0.33 mmol) is added and the mixture is stirred for 16 hrs. All the solvent is removed and the residue is purified by flash column chromatography to give 38 mg of the titled product.

Provenance & Evidence