HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 67055922, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(5-Bromopyridin-3-yl)acetonitrile | HCID 15005417 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67055922 | HCID 67055922 | 28% |
Reaction Steps
(5-Bromo-pyridin-3-yl)-acetonitrile (1.0 g, 0.005 mol) and 60% NaH (0.780 g) are mixed in DMF (25 mL) at 0° C. and stirred at room temperature for 1 h. MeI (1.2 ml) is added to this mixture at 0° C. and stirred at room temperature overnight. 2-(5-bromo-pyridin-3-yl)-propionitrile is obtained by prep-HPLC (0.3 g, 28% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-8f9afe5c0d2640869d7f23930a9231c2 |
| Source note | uspto-grants-2015_11 |