Pyridine → HCID 117667658, compound

Participants

Reaction Steps

1-Morpholin-4-yl-2-[5-(5,6,7,8-tetrahydro-[1,8]naphthyridin-3-yl)-pyridin-3-yl]-ethanone (62.4 mg, 0.184 mmol) is dissolved in DCM (2 mL). Pyridine (0.089 mL, 1.11 mmol) is added. Acetyl chloride (1.0M in DCM, 0.55 mL, 0.55 mmol) is added dropwise and the mixture is stirred for 16 h. The mixture is diluted with EtOAc (50 mL), washed with water (3×5 mL), and brine, dried over sodium sulfate, filtered, and concentrated. The resulting crude product is purified by normal phase chromatography using 0-6% MeOH in DCM as the gradient to afford the title compound.

Provenance & Evidence