HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 1633014-63-7
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-chloro-1,2,3,4-tetrahydro-1,8-naphthyridine | HCID 58516768 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1633014-63-7 | HCID 117667745 | 91.6% |
Reaction Steps
To a solution of 5-chloro-1,2,3,4-tetrahydro-[1,8]naphthyridine (500 mg, 3.0 mmol) in DCM (40 mL) is added N-bromosuccinimide (530 mg, 3.0 mmol). The reaction mixture is stirred at room temperature for 2 hrs. The reaction mixture is concentrated to give the crude product. Purification by flash column chromatography affords 680 mg of 6-bromo-5-chloro-1,2,3,4-tetrahydro-[1,8]naphthyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181272B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-518f038ee1934b28962cb8c8181f76ef |
| Source note | uspto-grants-2015_11 |