HCID 117667652, compound → HCID 117667552, compound

Participants

Reaction Steps

5-Fluoro-1,2,3,4-tetrahydro-[1,8]naphthyridine is converted to 6-bromo-5-fluoro-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide according to Step 1 and Step 2 of Example 121. 6-Bromo-5-fluoro-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide is coupled with 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-tetrahydro-pyran-4-ol (which is prepared according to Step 4 of Example 119) to give the titled product using Suzuki Coupling Method VI.

Provenance & Evidence