Triacetoxyperiodinane → HCID 117667201, compound

Participants

Reaction Steps

To a solution of 6-[5-fluoro-4-((S)-1-hydroxy-ethyl)-pyridin-3-yl]-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide (100 mg, 0.3 mmol, Compound 34, Example 16) in 5 mL of dichloromethane is added Dess-Martin periodinane (135 mg, 0.3 mmol, 1 eq.). The reaction is stirred at room temperature until the reaction is complete. The reaction mixture is filtered through diatomaceous earth and the filtrate is concentrated. The crude reaction product is purified by flash column chromatography to give 75 mg of the titled product.

Provenance & Evidence