Water → HCID 14463967, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2R,5R)-2-(tert-butyl)-5-(4-chlorobutyl)-3,5-dimethylimidazolidin-4-one (D45) (310 mg, 1.18 mmol) in dry MeCN (4 ml), anhydrous Na2CO3 (63 mg, 0.6 mmol) and NaI (178 mg, 1.18 mmol) were added sequentially. The solution was heated at 80° C. for 12 hrs. The reaction was allowed to cool at RT, poured into water (10 ml) and extracted with Et2O (3×10 ml). The organic phases were collected, washed with NaCl sat sol, dried over Na2SO4 and evaporated in vacuo to afford the title compound (D46) (220 mg)

Provenance & Evidence