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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712821Generated: October 28, 2026

1-(tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid → HCID 71187447, compound

https://huagongshe.com/reaction/712821

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acidHCID 10515301—
ReactantMethyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
ProductHCID 71187447HCID 7118744746.7%

Reaction Steps

The title compound (D58) (250 mg) was prepared according to the general procedure for amides preparation (Method C) starting from 1-(tert-butoxycarbonyl)-4,4-dimethylpiperidine-2-carboxylic acid (320 mg; described in J. Med. Chem. 1997, 40, 2491-2501) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (312 mg). Reaction time: 18 hrs

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-498abe02aae14fe7937f94a89c9f6f75
Source noteuspto-grants-2015_11