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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712828Generated: October 31, 2026

1-Hydroxybenzotriazole → HCID 117966735, compound

https://huagongshe.com/reaction/712828

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantMethyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
ReactantHCID 71147218HCID 71147218—
SolventWaterHCID 962—
ProductHCID 117966735HCID 11796673594.5%

Reaction Steps

The title compound (D69) (270 mg) was prepared according to the general procedure for amides preparation (Method A) starting from 3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-4-carboxylic acid (D17) (200 mg) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (157 mg). HOBT.H2O: 1.2 eq; Reaction time: 3 hrs.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-adca6559329f455a8c2e02d7626672f9
Source noteuspto-grants-2015_11