Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 71187343, compound

HRID 712829Notes

Reaction equation

HRID 712829 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@@H:14]([C:15]([OH:17])=O)[CH2:13][CH2:12][CH:11]2[CH:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:19][C:20]1([C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)[CH2:22][CH2:21]1>>[CH3:30][O:29][C:27]([C:26]1[CH:31]=[CH:32][C:23]([C:20]2([NH:19][C:15]([C@H:14]3[CH2:13][CH2:12][CH:11]4[CH:9]([CH2:10]4)[N:8]3[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[O:17])[CH2:21][CH2:22]2)=[CH:24][CH:25]=1)=[O:28]

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 71186412HCID 71186412, compound

Product 1

HCID 71187343HCID 71187343, compoundYield 16.3%

Procedure

The title compound (D70) (28 mg) was prepared according to the general procedure for amides preparation (Method C) starting from (3R)-2-(tert-butoxycarbonyl)-2-azabicyclo[4.1.0]heptane-3-carboxylic acid (D22) (100 mg) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (103 mg). Reaction time: 1 h

Workup

  1. customReaction time
  2. custom1 h

Sources & evidence

ORD record
ord-b00c859136784b5c9cd0a45276b7a41e
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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