(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 71187439, compound

HRID 712830Notes

Reaction equation

HRID 712830 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@@H:14]([C:15]([OH:17])=O)[CH2:13][CH2:12][CH:11]2[CH:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[NH2:19][C@H:20]([C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][CH:23]=1)[CH3:21]>>[CH3:29][O:28][C:26]([C:25]1[CH:30]=[CH:31][C:22]([C@@H:20]([NH:19][C:15]([C@H:14]2[CH2:13][CH2:12][CH:11]3[CH:9]([CH2:10]3)[N:8]2[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[O:17])[CH3:21])=[CH:23][CH:24]=1)=[O:27]

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 71186412HCID 71186412, compound

Product 1

HCID 71187439HCID 71187439, compoundYield 27.6%

Procedure

The title compound (D71) (46 mg) was prepared according to the general procedure for amides preparation (Method C) starting from (3R)-2-(tert-butoxycarbonyl)-2-azabicyclo[4.1.0]heptane-3-carboxylic acid (D22) (100 mg) and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (115 mg). Reaction time: 1 h

Workup

  1. customReaction time
  2. custom1 h

Sources & evidence

ORD record
ord-7b875d8b2e3047acb7de8c79bbec79ec
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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