HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate → HCID 117966845, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | HCID 42624899 | — |
| Reactant | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 4,4-diMethyl-, 1-(1,1-diMethylethyl) ester, (2R)- | HCID 94413384 | — |
| Product | HCID 117966845 | HCID 117966845 | 65.4% |
Reaction Steps
The title compound (D75) (94 mg) was prepared according to the general procedure for amides preparation (Method C) starting from (R)-1-(tert-butoxycarbonyl)-4,4-dimethylpyrrolidine-2-carboxylic acid (D41) (84 mg) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (79 mg). HCTU: 1.05 eq; Reaction time: 2 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-2d40a7624f8d468d83be25c37f57b30f |
| Source note | uspto-grants-2015_11 |