Triacetoxyperiodinane → HCID 89370062, compound

Participants

Reaction Steps

A solution of (2R,4R)-3-(trifluoromethyl)benzyl 4-hydroxy-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate (D81) (469 mg, 1.05 mmol) in dry DCM (10 ml) was treated with Dess-Martin periodinane (0.57 mg, 1.34 mmol) and stirred at RT 4 hrs. The reaction was quenched with 10% aqueous sodium sulphite solution (10 ml) and extracted with EtOAc (3×10 ml). The organic phases were collected, washed with NaCl sat. sol, dried over Na2SO4 and evaporated to afford a residue which was purified by SPE-Si cartridge (10 g) eluting with a mixture cHex/EtOAc 90/10. Collected fractions after solvent evaporation afforded the title compound (D83) (290 mg).

Provenance & Evidence