tert-Butyl carbamate → HCID 71186487, compound

HRID 712838Notes

Reaction equation

HRID 712838 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([CH:25]3[N:32](C(OC(C)(C)C)=O)[CH2:31][CH2:30][C:27]4([CH2:29][CH2:28]4)[CH2:26]3)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[CH2:28]1[C:27]2([CH2:30][CH2:31][NH:32][CH:25]([C:23]([NH:22][C:19]3([C:16]4[CH:17]=[CH:18][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:14][CH:15]=4)[CH2:20][CH2:21]3)=[O:24])[CH2:26]2)[CH2:29]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 117966881HCID 117966881, compound

Product 1

HCID 71186487HCID 71186487, compoundYield 103.5%

Procedure

The title compound (D88) (230 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 5-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate (racemic mixture) (D54) (290 mg).

Sources & evidence

ORD record
ord-0f49b59053aa4a089e18a583ca5f9b4b
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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