tert-Butyl carbamate → HCID 71186606, compound

HRID 712841Notes

Reaction equation

HRID 712841 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:21][C:22]([CH:24]2[N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][C:26]3([CH2:28][CH2:27]3)[CH2:25]2)=[O:23])[CH3:20])=[CH:15][CH:14]=1)=[O:12]>>[CH2:27]1[C:26]2([CH2:29][CH2:30][NH:31][CH:24]([C:22]([NH:21][C@H:19]([C:16]3[CH:17]=[CH:18][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:14][CH:15]=3)[CH3:20])=[O:23])[CH2:25]2)[CH2:28]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 71187398HCID 71187398, compound

Product 1

HCID 71186606HCID 71186606, compoundYield 97.2%

Procedure

The title compound (D91) (96 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 5-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate (D56) (130 mg).

Sources & evidence

ORD record
ord-503541af9ee040d28e0ec8015929cb80
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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