tert-Butyl carbamate → HCID 71186341, compound

HRID 712842Notes

Reaction equation

HRID 712842 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:21][C:22]([C:24]2([CH3:39])[N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29][C:26]3([CH2:28][CH2:27]3)[CH2:25]2)=[O:23])[CH3:20])=[CH:15][CH:14]=1)=[O:12]>>[CH3:39][C:24]1([C:22]([NH:21][C@H:19]([C:16]2[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=2)[CH3:20])=[O:23])[NH:31][CH2:30][CH2:29][C:26]2([CH2:27][CH2:28]2)[CH2:25]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 117966958HCID 117966958, compound

Product 1

HCID 71186341HCID 71186341, compoundYield 99%

Procedure

The title compound (D92) (19 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 5-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)-5-methyl-6-azaspiro[2.5]octane-6-carboxylate (D57) (25 mg)

Sources & evidence

ORD record
ord-9238d0e2d7b347bdb954cf176837575c
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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