tert-Butyl carbamate → HCID 71186596, compound

HRID 712843Notes

Reaction equation

HRID 712843 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([CH:25]3[CH2:30][C:29]([CH3:32])([CH3:31])[CH2:28][CH2:27][N:26]3C(OC(C)(C)C)=O)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[CH3:31][C:29]1([CH3:32])[CH2:28][CH2:27][NH:26][CH:25]([C:23]([NH:22][C:19]2([C:16]3[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=3)[CH2:21][CH2:20]2)=[O:24])[CH2:30]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 71187447HCID 71187447, compound

Product 1

HCID 71186596HCID 71186596, compoundYield 78.2%

Procedure

The title compound (D93) (150 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-4,4-dimethylpiperidine-1-carboxylate (D58) (250 mg)

Sources & evidence

ORD record
ord-316644a95de64831a1a55cfa00d0040a
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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