tert-Butyl carbamate → HCID 71186476, compound

HRID 712844Notes

Reaction equation

HRID 712844 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:21][C:22]([CH:24]2[CH2:29][C:28]([CH3:31])([CH3:30])[CH2:27][CH2:26][N:25]2C(OC(C)(C)C)=O)=[O:23])[CH3:20])=[CH:15][CH:14]=1)=[O:12]>>[CH3:31][C:28]1([CH3:30])[CH2:27][CH2:26][NH:25][CH:24]([C:22]([NH:21][C@H:19]([C:16]2[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=2)[CH3:20])=[O:23])[CH2:29]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 71187444HCID 71187444, compound

Product 1

HCID 71186476HCID 71186476, compoundYield 85.7%

Procedure

The title compound (D94) (150 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 2-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)-4,4-dimethylpiperidine-1-carboxylate (diastereoisomers mixture) (D59) (230 mg)

Sources & evidence

ORD record
ord-1b0b78203a5e4264a8f4d90155f85084
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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