tert-Butyl carbamate → HCID 71186614, compound

HRID 712845Notes

Reaction equation

HRID 712845 reaction equation
C(=O)(OC(C)(C)C)N.[F:9][CH:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[C@@H:12]([C:23](=[O:37])[NH:24][C@H:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([O:35][CH3:36])=[O:34])=[CH:29][CH:28]=2)[CH3:26])[CH2:11]1>>[F:9][CH:10]1[CH2:15][CH2:14][NH:13][C@@H:12]([C:23]([NH:24][C@H:25]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([O:35][CH3:36])=[O:34])=[CH:31][CH:32]=2)[CH3:26])=[O:37])[CH2:11]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 117966723HCID 117966723, compound

Product 1

HCID 71186614HCID 71186614, compoundYield 111.6%

Procedure

The title compound (D95) (75 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (2R)-tert-butyl 4-fluoro-2-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)piperidine-1-carboxylate (D62) (89 mg).

Sources & evidence

ORD record
ord-ebddb533950748b094c232363b870d23
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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