tert-Butyl carbamate → HCID 71186417, compound

HRID 712846Notes

Reaction equation

HRID 712846 reaction equation
C(=O)(OC(C)(C)C)N.[F:9][CH:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[C@@H:12]([C:23](=[O:38])[NH:24][C:25]2([C:28]3[CH:33]=[CH:32][C:31]([C:34]([O:36][CH3:37])=[O:35])=[CH:30][CH:29]=3)[CH2:27][CH2:26]2)[CH2:11]1>>[F:9][CH:10]1[CH2:15][CH2:14][NH:13][C@@H:12]([C:23]([NH:24][C:25]2([C:28]3[CH:29]=[CH:30][C:31]([C:34]([O:36][CH3:37])=[O:35])=[CH:32][CH:33]=3)[CH2:26][CH2:27]2)=[O:38])[CH2:11]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 71186625HCID 71186625, compound

Product 1

HCID 71186417HCID 71186417, compoundYield 87.5%

Procedure

The title compound (D96) (26 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (2R)-tert-butyl 4-fluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate (D65) (39 mg).

Sources & evidence

ORD record
ord-e15aba24ce32462e8185799b07fd4d87
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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