tert-Butyl carbamate → HCID 71204651, compound

HRID 712847Notes

Reaction equation

HRID 712847 reaction equation
C(=O)(OC(C)(C)C)N.[F:9][C:10]1([F:38])[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[C@@H:12]([C:23](=[O:37])[NH:24][C@H:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([O:35][CH3:36])=[O:34])=[CH:29][CH:28]=2)[CH3:26])[CH2:11]1>>[F:38][C:10]1([F:9])[CH2:15][CH2:14][NH:13][C@@H:12]([C:23]([NH:24][C@H:25]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([O:35][CH3:36])=[O:34])=[CH:29][CH:28]=2)[CH3:26])=[O:37])[CH2:11]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 117966793HCID 117966793, compound

Product 1

HCID 71204651HCID 71204651, compoundYield 88%

Procedure

The title compound (D97) (66 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (R)-tert-butyl 4,4-difluoro-2-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)piperidine-1-carboxylate (D66) (98 mg).

Sources & evidence

ORD record
ord-c24fcc3fadd5497080323f1a17de5044
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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