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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712849Generated: October 27, 2026

tert-Butyl carbamate → Methyl 4-(1-(4,4-difluoropiperidine-2-carboxamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/712849

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl carbamateHCID 77922—
ReactantTert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylateHCID 117966874—
ProductMethyl 4-(1-(4,4-difluoropiperidine-2-carboxamido)cyclopropyl)benzoateHCID 7118648694.6%

Reaction Steps

The title compound (D99) (500 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 4,4-difluoro-2-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)piperidine-1-carboxylate (D68) (685 mg)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-68e1cbdbd6cd470fba205a3a006be5c8
Source noteuspto-grants-2015_11