tert-Butyl carbamate → HCID 71186306, compound

HRID 712850Notes

Reaction equation

HRID 712850 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2([NH:22][C:23]([CH:25]3[CH2:31][CH:30]4[CH:28]([CH2:29]4)[CH2:27][N:26]3C(OC(C)(C)C)=O)=[O:24])[CH2:21][CH2:20]2)=[CH:15][CH:14]=1)=[O:12]>>[CH:28]12[CH2:29][CH:30]1[CH2:31][CH:25]([C:23]([NH:22][C:19]1([C:16]3[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=3)[CH2:20][CH2:21]1)=[O:24])[NH:26][CH2:27]2

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 117966735HCID 117966735, compound

Product 1

HCID 71186306HCID 71186306, compoundYield 78.6%

Procedure

The title compound (D100) (155 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from tert-butyl 4-((1-(4-(methoxycarbonyl)phenyl)cyclopropyl)carbamoyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate (D69) (260 mg).

Sources & evidence

ORD record
ord-0a7df4b794654315afe2b8fe753222ab
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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