tert-Butyl carbamate → HCID 71204700, compound

HRID 712852Notes

Reaction equation

HRID 712852 reaction equation
C(=O)(OC(C)(C)C)N.[CH3:9][O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C@@H:19]([NH:21][C:22]([C@H:24]2[CH2:30][CH2:29][CH:28]3[CH:26]([CH2:27]3)[N:25]2C(OC(C)(C)C)=O)=[O:23])[CH3:20])=[CH:15][CH:14]=1)=[O:12]>>[CH:26]12[CH2:27][CH:28]1[CH2:29][CH2:30][C@H:24]([C:22]([NH:21][C@H:19]([C:16]1[CH:15]=[CH:14][C:13]([C:11]([O:10][CH3:9])=[O:12])=[CH:18][CH:17]=1)[CH3:20])=[O:23])[NH:25]2

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 71187439HCID 71187439, compound

Product 1

HCID 71204700HCID 71204700, compoundYield 50.6%

Procedure

The title compound (D102) (17.5 mg) was prepared according to the general procedure for t-Butyl carbamate (Boc) cleavage starting from (3R)-tert-butyl 3-(((S)-1-(4-(methoxycarbonyl)phenyl)ethyl)carbamoyl)-2-azabicyclo[4.1.0]heptane-2-carboxylate (diastereoisomers mixture) (D71) (46 mg).

Sources & evidence

ORD record
ord-8a1821f74e7149b6a095ac898707c9f2
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

Loading…