1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 71186594, compound

Participants

Reaction Steps

To a solution of methyl 4-(1-(6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate 2,2,2-trifluoroacetate (D89) (27 g, 61.03 mmol) in dry MeCN (900 ml) Cs2CO3 (39.7 g, 122.05 mmol) and a solution of 4-(trifluoromethyl)-benzylbromide (14.6 g, 61.03 mmol) in MeCN (50 ml) were added in sequence. The mixture was stirred at RT for 18 hrs. The solid was filtered off and solvents were evaporated. The residue was ri-dissolved in DCM (200 ml) and washed with H2O (3×100 ml) and NaCl sat. sol (50 ml). The organic phases were dried over Na2SO4 and evaporated to afford a white solid, which was triturated in cyclohexane to afford the title compound (D123) (19.7 g).

Provenance & Evidence