HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 71186482, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-(Chloromethyl)-2-(trifluoromethyl)pyridine | HCID 2773810 | — |
| Reactant | HCID 71186594 | HCID 71186594 | — |
| Product | HCID 71186482 | HCID 71186482 | 93.8% |
Reaction Steps
The title compound (D124) (47 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate (D90) (50 mg) and 3-chloromethyl-6-(trifluoromethyl)piridine (38 mg). (Cs2CO3: 1.3 eq; reaction time: 18 hrs; RT)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-67169936f6354f3395f222c164baa19b |
| Source note | uspto-grants-2015_11 |