HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 71186223, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Reactant | HCID 71186605 | HCID 71186605 | — |
| Product | HCID 71186223 | HCID 71186223 | 113.4% |
Reaction Steps
The title compound (D125) (60.7 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-(1-(6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl)benzoate 2,2,2-trifluoroacetate (single unknown enantiomer) (D90) (50 mg, 0.11 mmol) and 3-(Trifluoromethyl)benzyl bromide (0.020 ml, 0.12 mmol). (Cs2CO3:2 eq; reaction time: 4 hrs; reaction temperature: RT.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-cec13cd41aac47cc95ba8a892c2f55ea |
| Source note | uspto-grants-2015_11 |