HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 71204656, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(Bromomethyl)-4-(trifluoromethyl)benzene | HCID 123062 | — |
| Reactant | HCID 71186614 | HCID 71186614 | — |
| Product | HCID 71204656 | HCID 71204656 | — |
Reaction Steps
The title compound (D133) (62 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-((1S)-1-((2R)-4-fluoropiperidine-2-carboxamido)ethyl)benzoate (D95) (75 mg) and 4-(trifluoromethyl)-benzylbromide (0.045 ml). (Cs2CO3: 1.3 eq; reaction time: 18 hrs; RT).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181279B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-c261d303ed7341df86cacdf28f5a8476 |
| Source note | uspto-grants-2015_11 |