Cesium carbonate → HCID 71204702, compound

HRID 712872Notes

Reaction equation

HRID 712872 reaction equation
[F:1][CH:2]1[CH2:7][CH2:6][NH:5][C@@H:4]([C:8]([NH:10][C:11]2([C:14]3[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=3)[CH2:13][CH2:12]2)=[O:9])[CH2:3]1.[F:24][C:25]([F:35])([F:34])[C:26]1[CH:33]=[CH:32][C:29]([CH2:30]Br)=[CH:28][CH:27]=1.C([O-])([O-])=O.[Cs+].[Cs+]>>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:30][C:29]2[CH:28]=[CH:27][C:26]([C:25]([F:24])([F:34])[F:35])=[CH:33][CH:32]=2)[C@@H:4]([C:8]([NH:10][C:11]2([C:14]3[CH:15]=[CH:16][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:22][CH:23]=3)[CH2:12][CH2:13]2)=[O:9])[CH2:3]1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 71186417HCID 71186417, compound

Product 1

HCID 71204702HCID 71204702, compound

Procedure

The title compound (D134) (26 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-(1-((2R)-4-fluoropiperidine-2-carboxamido)cyclopropyl)benzoate (D96) (39 mg) and 4-(trifluoromethyl)-benzylbromide (0.015 ml). (Cs2CO3: 1.3 eq; reaction time: 18 hrs; RT).

Sources & evidence

ORD record
ord-c66d15ea69144bb3aeaaeeafaf7e95fc
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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