1-(Bromomethyl)-4-(trifluoromethyl)benzene → HCID 71204689, compound

HRID 712874Notes

Reaction equation

HRID 712874 reaction equation
[F:1][C:2]1([F:24])[CH2:7][CH2:6][NH:5][C@@H:4]([C:8]([NH:10][C:11]2([C:14]3[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=3)[CH2:13][CH2:12]2)=[O:9])[CH2:3]1.[F:25][C:26]([F:36])([F:35])[C:27]1[CH:34]=[CH:33][C:30]([CH2:31]Br)=[CH:29][CH:28]=1>>[F:24][C:2]1([F:1])[CH2:7][CH2:6][N:5]([CH2:31][C:30]2[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:35])[F:36])=[CH:34][CH:33]=2)[C@@H:4]([C:8]([NH:10][C:11]2([C:14]3[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=3)[CH2:12][CH2:13]2)=[O:9])[CH2:3]1

Participants

3

Reactant 2

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 71204720HCID 71204720, compound

Product 1

HCID 71204689HCID 71204689, compound

Procedure

The title compound (D136) (30 mg) was prepared according to the general procedure described in Description 135 starting from (R)-methyl 4-(1-(4,4-difluoropiperidine-2-carboxamido)cyclopropyl)benzoate (D98) (47 mg) and 4-(trifluoromethyl)-benzylbromide (0.027 ml).

Sources & evidence

ORD record
ord-ebff8b264396494ca4a259cf56bb285b
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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