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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 71288생성일: 2026년 10월 25일

1-(4-Fluorophenyl)ethylamine → (+)-n-(2-Chloro-5-fluoropyrimidinyl)-1-(4-fluorophenyl)ethylamine

https://huagongshe.com/reaction/71288

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참여 물질

역할이름HCID투입량
반응물1-(4-Fluorophenyl)ethylamineHCID 123063—
반응물2,4-Dichloro-5-fluoropyrimidineHCID 250705—
생성물(+)-n-(2-Chloro-5-fluoropyrimidinyl)-1-(4-fluorophenyl)ethylamineHCID 79080435—

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In like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro 4-pyrimidineamine, 4-fluoro-α-methylbenzylamine and 2,4-dichloro-5-fluoropyrimidine were reacted to produce (±)-N-(2-chloro-5-fluoropyrimidinyl)-1-(4-fluorophenyl)ethylamine. 1H NMR (CDCl3): δ 7.87 (d, 1H, J=2.3 Hz), 7.37-7.33 (dd, 2H, J=5.4 and 8.4 Hz), 7.04 (t, 2H, J=8.4 Hz), 5.35-5.31 (m, 2H), 1.60 (d, 3H, J=6.4 Hz); LCMS: ret. time: 32.90 min.; purity: 98%; MS (m/e): 270 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08822685B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-a178fb371e56410f90e6885b693eb269
출처 메모uspto-grants-2014_09