1-(Bromomethyl)-3-(trifluoromethyl)benzene → HCID 117966919, compound

HRID 712881Notes

Reaction equation

HRID 712881 reaction equation
[C@@H:1]12[CH2:6][C@@H:5]1[CH2:4][C@H:3]([C:7]([NH:9][C:10]1([C:13]3[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=3)[CH2:12][CH2:11]1)=[O:8])[NH:2]2.[F:23][C:24]([F:34])([F:33])[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28]Br>>[F:23][C:24]([F:33])([F:34])[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][N:2]1[C@@H:3]([C:7]([NH:9][C:10]2([C:13]3[CH:14]=[CH:15][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:21][CH:22]=3)[CH2:11][CH2:12]2)=[O:8])[CH2:4][CH:5]2[CH:1]1[CH2:6]2

Participants

3

Reactant 2

HCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzeneHCID 71186368HCID 71186368, compound

Product 1

HCID 117966919HCID 117966919, compoundYield 121.8%

Procedure

The title compound (D146) (67 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl methyl 4-(1-((3R)-2-azabicyclo[3.1.0]hexane-3-carboxamido)cyclopropyl)benzoate (D104) (37 mg, 0.12 mmol) and 3-(Trifluoromethyl)benzyl bromide (0.029 ml, 0.19 mmol).

Sources & evidence

ORD record
ord-a472f081993c4bc3b8383b3f447c0567
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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