Acetonitrile → HCID 71204698, compound

Participants

Reaction Steps

To a solution of methyl 4-(1-((1R,3R,5R)-2-azabicyclo[3.1.0]hexane-3-carboxamido)cyclopropyl)benzoate (D104) (1.7 g, 5.7 mmol) in MeCN (80 ml) Cs2CO3 (2.8 g, 8.5 mmol) and 4-(trifloromethyl)benzylbromide (1.6 g, 6.8 mmol) were added and the resulting mixture was stirred at RT for 4 hrs. Solvent was evaporated and the residue was loaded on a SNAP-Si cartridge (100 g), eluted with a mixture DCM/AcOEt from 10/0 to DCM/AcOEt 9/1. Collected fractions after solvent evaporation afforded the title compound (D147) (2.41 g).

Provenance & Evidence