Sodium Carbonate → HCID 71204658, compound

HRID 712884Notes

Reaction equation

HRID 712884 reaction equation
[CH:1]12[CH2:6][CH:5]1[CH2:4][C@H:3]([C:7]([NH:9][C@H:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)[CH3:11])=[O:8])[NH:2]2.[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1.C([O-])([O-])=O.[Na+].[Na+]>>[F:22][C:23]([F:32])([F:33])[C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:2]2[C@@H:3]([C:7]([NH:9][C@H:10]([C:12]3[CH:13]=[CH:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:20][CH:21]=3)[CH3:11])=[O:8])[CH2:4][CH:5]3[CH:1]2[CH2:6]3)=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 71204727HCID 71204727, compound

Product 1

HCID 71204658HCID 71204658, compound

Procedure

The title compounds (D149) (14 mg) was prepared according to the general procedure for substituted benzyl amines preparation starting from methyl 4-((1S)-1-((3R)-2-azabicyclo[3.1.0]hexane-3-carboxamido)ethyl)benzoate (D106) (11 mg) and 4-(trifluoromethyl)-benzylbromide (0.007 ml). (Na2CO3: 3 eq; Reaction time: 18 hrs; 68° C.)

Sources & evidence

ORD record
ord-a0ac61c760894758a342277d4ec6e28d
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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