Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → HCID 71204695, compound

HRID 712890Notes

Reaction equation

HRID 712890 reaction equation
[CH3:1][C@:2]1([C:19]([O-:21])=O)[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1.[Li+].Cl.[NH2:24][C:25]1([C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=2)[CH2:27][CH2:26]1>>[CH3:1][C@:2]1([C:19]([NH:24][C:25]2([C:28]3[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][CH:29]=3)[CH2:27][CH2:26]2)=[O:21])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 66824369Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 131733993HCID 131733993, compound

Product 1

HCID 71204695HCID 71204695, compoundYield 16.2%

Procedure

The title compound (D157) (5 mg) was prepared according to the general procedure for amides preparation (Method B) starting from lithium (R)-2-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxylate (D112) (20 mg) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (17.2 mg).

Sources & evidence

ORD record
ord-bba698d06194437682c7c184933d3ec2
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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