(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 71204662, compound

HRID 712891Notes

Reaction equation

HRID 712891 reaction equation
[CH3:1][C@:2]1([C:19]([O-])=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1.[Li+].Cl.[NH2:24][C@H:25]([C:27]1[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=1)[CH3:26]>>[CH3:1][C@:2]1([C:19]([NH:24][C@H:25]([C:27]2[CH:36]=[CH:35][C:30]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:28]=2)[CH3:26])=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:17])([F:16])[F:18])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 131733993HCID 131733993, compound

Product 1

HCID 71204662HCID 71204662, compoundYield 33.2%

Procedure

The title compound (D158) (10 mg) was prepared according to the general procedure for amides preparation (Method B) starting from lithium (R)-2-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-2-carboxylate (D112) (20 mg) and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride (16.32 mg).

Sources & evidence

ORD record
ord-5844a7fd127248889bcb87183b06c96a
Source dataset
uspto-grants-2015_11
Patent number
US09181279B2

Reaction notes

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