HCID 71204713, compound → HCID 71204714, compound

Participants

Reaction Steps

A suspension of methyl 4-((S)-1-((R)-4,4-difluoro-1-(3-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D164) (33 mg) and 10% w Pd/C (5 mg) in MeOH (5 ml) and 1M HCl (0.5 ml) was stirred under a constant current of H2 for 3 hrs. Catalyst was filtered off and solvent evaporated to afford a residue which was triturated with cHex and filtered to afford the title compound (D165) (30 mg).

Provenance & Evidence