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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 712926Generated: October 30, 2026

Lithium hydroxide, monohydrate → HCID 71204699, compound

https://huagongshe.com/reaction/712926

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium hydroxide, monohydrateHCID 168937—
ReactantHCID 71204697HCID 71204697—
ProductHCID 71204699HCID 7120469973.6%

Reaction Steps

The title compound (E45) (12 mg) was prepared according to the general procedure for esters hydrolysis (Method D) starting from methyl 4-((S)-1-((R)-4,4-difluoro-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamido)ethyl)benzoate (D166) (16.8 mg). (LiOH H2O: 3 eq; reaction time: 18 hrs)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181279B2
Source datasetuspto-grants-2015_11
ORD IDord-0faeebd8d50e46b7994f2f89bc363f2b
Source noteuspto-grants-2015_11