HCID 131734004, compound → Trifluoroacetic acid

Participants

Reaction Steps

A mixture of 6-benzyl-N-cyclopropyl-3-(4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine TFA salt (5 mg, 8.10 μmol) and Pd(OH)2 on carbon, (20 wt %, 1 mg, 7.12 μmol) in THF (80 μL) was stirred under atmosphere of hydrogen gas (balloon) at rt. After 1 h, the mixture was purified by HPLC Method A to give the title compound as a TFA salt (4.6 mg, 100%) as a yellow film; ESI-MS m/z [M+H]+ 414.4.

Provenance & Evidence