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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 713257Generated: November 4, 2026

HCID 131734017, compound → Trifluoroacetic acid

https://huagongshe.com/reaction/713257

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 131734017HCID 131734017—
CatalystPalladium hydroxideHCID 9942167—
SolventTetrahydrofuranHCID 8028—
ProductTrifluoroacetic acidHCID 6422440.3%
ProductHCID 118159354HCID 118159354—

Reaction Steps

A solution of 6-benzyl-N-(tert-butyl)-3-(4-(2,4-difluorophenoxyl)piperidin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine TFA salt (155 mg, 0.249 mmol) and Pd(OH)2 on carbon (35.0 mg, 0.050 mmol) in THF (2.49 mL) was purged and placed under hydrogen (balloon) atmosphere for 2 h. Filtration through Celite™ and concentration gave the title compound as a TFA salt (125 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181249B2
Source datasetuspto-grants-2015_11
ORD IDord-9552b36451fd413e9bdb24885f25a6a1
Source noteuspto-grants-2015_11