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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 713263Generated: November 1, 2026

HCID 131734021, compound → Trifluoroacetic acid

https://huagongshe.com/reaction/713263

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 131734021HCID 131734021—
CatalystPalladium hydroxideHCID 9942167—
SolventTetrahydrofuranHCID 8028—
ProductTrifluoroacetic acidHCID 6422480.4%
ProductHCID 118159154HCID 118159154—

Reaction Steps

A solution of 6-benzyl-3-(4-(2,4-difluorophenoxyl)piperidin-1-yl)-N-isopropyl-5-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine TFA salt (150 mg, 0.241 mmol) and Pd(OH)2 on carbon (16.9 mg, 0.024 mmol) in THF (1.21 mL) was purged and placed under hydrogen atmosphere (balloon) overnight. The mixture was then filtered through Celite™ and concentrated to give the title compound as its TFA salt (132 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181249B2
Source datasetuspto-grants-2015_11
ORD IDord-c1af886b308d4c928a02b917311a76d0
Source noteuspto-grants-2015_11