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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 713264Generated: November 1, 2026

HCID 131734022, compound → Trifluoroacetic acid

https://huagongshe.com/reaction/713264

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 131734022HCID 131734022—
CatalystPalladium hydroxideHCID 9942167—
SolventTetrahydrofuranHCID 8028—
ProductTrifluoroacetic acidHCID 6422479%
ProductHCID 118159175HCID 118159175—

Reaction Steps

A solution of 6-benzyl-N-(2,2-difluoroethyl)-3-(4-(2,4-difluorophenoxyl)piperidin-1-yl)-5-methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine TFA salt (160 mg, 0.249 mmol) and Pd(OH)2 on carbon (17.5 mg, 0.025 mmol) in THF (1.24 mL) was purged and placed under hydrogen atmosphere (balloon) overnight. The mixture was filtered through Celite™ and concentrated to give title compound as its TFA salt (136 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09181249B2
Source datasetuspto-grants-2015_11
ORD IDord-9b81f2c9f1824cfc9e3de72488d22fcc
Source noteuspto-grants-2015_11